Pharmacokinetics : Few questions
You Guys Must be wondering,
Why I am not posting all questions at once . Actually , Basic Idea is to make you guys study every day at least
2-3 hours .This is my formula , if you
spent about 2-3 hours every day ,
You will pass this exam for sure .
Just Find out the answers for these questions and leave a comment Once again please confirm the answers with a authentic source
1. Correct statements
about bioavailability include:
A. pertains to the rate
and extent of drug absorption
B. for two dosage forms
of a drug to be considered equally
bioavailable, the
measured AUC for each drug must be equal
C. for two dosage forms
of a drug to be therapeutically equivalent
They must be equally
bioavailable
D. equally bioavailable
dosage forms may not necessarily be
Bioequivalent
1. A,B,C
2. A,C
3. B,D
4. D only
5. All are correct
correct answer: 4
2. Correct statements
pertaining to first-order elimination kinetics include:
A. a constant amount of
drug is eliminated per unit of time
B. this pattern of drug elimination
is most likely when elimination
Pathways are saturated
C. clearance will vary
as blood concentrations change
D. for drugs following
this elimination pattern, doubling the rate of
Administration will
yield a doubling of serum or plasma
Concentration at
steady-state
1. A,B,C
2. A,C
3. B,D
4. D only
5. All are correct
answer: 5 category
3. Correct statements
pertaining to protein-binding include:
A. acidic drugs are most
likely to be bound to albumin
B. the degree to which a
drug is protein-bound in plasma will affect
Its apparent volume of
distribution
C. basic drugs are most
likely to be bound to alpha 1-acid
Glycoprotein
D. for highly
protein-bound drugs, decreasing the extent of
Protein-binding in plasma
will enhance the rate of glomerular
Filtration
1. A,B,C
2. A,C
3. B,D
4. D only
5. All are Correct
answer: 3 category: Pharmacokinetics
4. Correct statements
pertaining to elimination half-life include:
A. elimination half-life
always increases as clearance decreases
B. knowledge of a drug's
elimination half-life allows one to estimate
The time necessary for
steady-state to be reached after starting
Therapy
C. for drugs that follow
first-order elimination kinetics, increasing
Drug dosage will
increase the elimination half-life
D. elimination half-life
is the time required for the amount of drug
In the body to be
reduced by 50%
1. A,B,C
2. A,C
3. B,D
4. D only
5. All are correct
Answer: 1
5. Phase II (synthetic)
reactions include:
A. glucuronidation
B. N-acetylation
C. O-methylation
D. hydrolysis
1. A,B,C
2. A,C
3. B,D
4. D only
5. All are correct
answer: 4
6. Metabolic pathways
which are subject to induction and inhibition by some
Drugs include:
A. sulfate conjugation
B. acetylating
C. glycine conjugation
D. oxidation
1. A,B,C
2. A,C
3. B,D
4. D only
5. All are correct
answer: 5
7. Some drugs are hepatic
ally metabolized and possess a high extraction ratio.
Correct statements
concerning these drugs include:
A. these drugs are
subject to extensive first-pass metabolism
B. inducing the hepatic microtonal
enzyme system is not likely to
Alter clearance
substantially
C. clearance of these
drugs is likely to be reduced in patients with
Congestive heart failure
D. administration of
these drugs parent rally will increase
Bioavailability
1. A,B,C
2. A,C
3. B,D
4. D only
5. All are correct
answer: 2
8. J.B. is 55 KG,
38-year-old male smoker with acute exacerbation of COPD who is
started on theophylline
in the ER. A loading dose of 300 mg is administered
over 30 minutes. Blood
samples obtained 3 hours and 6 hours after the loading
dose revealed serum
concentrations of 12.0 mg/L and 8.1 mg/L, respectively.
The elimination
half-life of theophylline in this patient is:
1. 0.53 hours
2. 5.33 hours
3. 3.50 hours
4. 6.00 hours
5. 8.03 hours
Answer: 4
9. Gentamicin
pharmacokinetics can be described using a 1 compartment model,
undergoes first order
metabolism, and is entirely cleared from the body
unchanged by the
kidneys. If a patient with a creatine clearance of 30 ml/min
is given gentamicin,
correct statements include:
1. compared to an
identical person with normal renal function (125 ml/min)
this patient's loading
dose should be reduced by 75%
2. if this patient
receives the same loading dose as an identical person
with normal renal
function, this patient's blood concentration will be
approximately 4 times
higher
3. a loading dose should
not be given to individuals who will clear a drug
from their body more
slowly than a normal population
4. this patient should
receive the same loading dose of gentamicin as an
Individual with normal
renal function
Answer: 1
10. Correct statements
pertaining to elimination half-life include:
A. if total body
clearance of drug A remains constant and the volume
of drug A distribution
is doubled, elimination half-life is
Increased
B. if total body
clearance of drug A is doubled and drug A volume of
Distribution remains
constant, elimination half-life is reduced
C. if a reduction in
total body clearance of drug A is accompanied by
a corresponding
reduction in drug A volume of distribution,
Elimination half-life
will remain unchanged
D. if a reduction in
total body clearance of drug A is accompanied by
an increase in drug A
volume of distribution, elimination half-
life will remain
unchanged
1. A,B,C
2. A,C
3. B,D
4. D only
5. All are correct
Answer 3